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Although direct inhibition of GPX4 has emerged as a canonical strategy to induce ferroptosis, its clinical translation remains challenging owing to systemic toxicity and poor pharmacological properties 124

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It is depleted in Parkinson's patients, which may accelerate neurodegeneration

doi: 10.1016/j.jacc.2019.07.020

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Dos-Santos-Pereira M., Acua L., Hamadat S., Rocca J., Gonzlez-Lizrraga F., Chehn R., Sepulveda-Diaz J., Del-Bel E., Raisman-Vozari R., Michel P.P