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Another piece of evidence that intestinal oxygen dynamics plays a key role in ferroptosis-mediated microbe-host interactions is that the oxygen gradient established in the gut under physiological conditions is crucial for maintaining microbial ecological balance

Malabsorption due to digestive disorders, such as Crohns disease or celiac disease, can also lead to vitamin B12 deficiency

One way to solve this problem is to activate the PI3K/Akt-mTOR pathway, downstream of the IGF-I pathway, by other means

The intestinal lining contains GLP-1 receptors that, when activated, may influence digestive processes, though the exact mechanisms are still being studied

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Trends Pharmacol Sci 27:639645 Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria