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Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling
Studies measuring CSF levels of lysosomal hydrolases (involved in the -Syn degradation) found decreased (Balducci et al., 2013b), or increased (Parnetti et al., 2014a) -hexosaminidase, increased cathepsin E (van Dijk et al., 2013b), decreased -mannosidase (Balducci et al., 2011
Close clinical monitoring is recommended for patients receiving parenteral nutrition for more than 30 days, especially those with underlying liver dysfunction, iron deficiency, or alterations in dopaminergic and catecholaminergic metabolism
PLoS One 7:e46563
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