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The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity

Here is a summary of the most commonly used DSIP dosing protocol based on available reports: Starting DSIP dose: 100mcg administered at night, preferably three hours before bedtime

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