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Phase 1 reaction involves oxidation, reduction, hydrolysis, hydration and many other rare chemical reactions

IKE not only enhances aqueous solubility but also boosts its anticancer properties

For topical formulations, concentrations of 0.1 to 0.3 percent are used, with efficacy detectable from as low as 0.01 percent

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At the same time, it enhances fibroblast activity through the FAK-paxillin cascade, which upregulates growth hormone receptors in soft tissue