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A total of 41% of the study volunteers had nausea, which varied in severity: Mild: 21% Moderate: 3% Severe: 15% Further, about 56% of the study volunteers complained of stretching and yawning, which also varied in severity: Mild: 36% Moderate: 13% Severe: 8% Other recorded side effects included in this review were flushing, increased or decreased appetite, and drowsiness

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A clinically significant interaction exists between tirzepatide and oral contraceptives, requiring backup contraception for 4 weeks after initiation and each dose increase, and patients taking levothyroxine or other time-sensitive medications warrant closer monitoring

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