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Furthermore, since CHE is an early sign of decompensation, the hazard ratio for mortality in patients with CHE is two to four times higher in affected patients [23, 24]

Interestingly, TFR1 had been previously identified as the major cell surface receptor for IgA1 binding in renal mesangial cells and its overexpression has been correlated with the proliferation of mesangial cells in IgAN patients [269,270,271]

from Taube and Schwartzkroin, 1987)

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