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There were no clear differences in subject demographics or key baseline characteristics between men and women, with the exception of weight (men tended to be heavier) and smoking status (51.7 vs 26.1% and 56.1 vs 23.0% of men vs women had a history of smoking in the semaglutide and placebo groups, respectively)

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Treatment always begins with the 2.5 mg dose administered once weekly for four weeks, serving as a tolerability-building dose rather than a therapeutic dose

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The FDA ended shortage-related compounding in 2025 and, on April 30, 2026, proposed keeping tirzepatide off the 503B bulks list permanently