If NNMT inhibition both restores adipocyte energy expenditure (promoting fat reduction) and supports myogenic differentiation (preserving or enhancing muscle), the net body composition effect could be recomposition simultaneous fat loss and lean mass preservation
If you have any sort of GI issue (GERD, reflux, SIBO/SIFO, yeast problems, chronic constipation, etc.) you will have problems taking oral forms of vitamin B12
This dual action of promoting fat breakdown while simultaneously reducing fat storage creates the net effect of adipose tissue reduction, all occurring at the peripheral tissue level without involvement of central appetite-regulating pathways in the hypothalamus
Common (1-10 in 100 people): headache, mild nausea, flushing or warm feeling in the face or neck from niacinamide
Fatigue can have many causes, including stress, poor sleep, hormone issues, nutritional deficiencies, or other medical concerns
Each has its own evidence base and safety boundary