Not evaluated by the FDA
What Has to Go Right Foundayo must convert its early 20,000-patient base into a sustained commercial ramp, with commercial PBM access confirmed at 2 of 3 major PBMs by mid-May and Medicare Bridge access beginning July 1, 2026 International Mounjaro must sustain above-50% share across 55+ launched countries and expand patient activation in penetration-early markets, with Brazil and Korea already demonstrating 60% share as a proof point Retatrutide Phase III data (TRIUMPH-1, due later in Q2) must confirm the weight loss profile seen in TRANSCEND-T2D-1, where participants lost 25 to 37 pounds on average, validating the next leg of the incretin portfolio Operating margin must hold near 49% or expand further, which Q1s 7 percentage point YoY non-GAAP margin improvement suggests is achievable as revenue scales faster than SG&A and R&D What Could Still Go Wrong U.S
Its established role within peptide research has resulted in extensive investigation across numerous experimental models examining cellular signalling processes
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Shah PJR, Green NA, Adib RS, et al
