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Various molecular and cellular pathologies are associated with these NDDs, including oxidative stress, mitochondrial dysfunction, calcium (Ca 2+ ) influx, glutamate toxicity, proteolytic stress, protein aggregation, neuroinflammation, and neuronal death [11, 12]

Since adiponectin, which is elevated in plasma in G49-treated mice (Figs

That is significantly more restrictive than the FDA threshold

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So, ipramarylin is the most commonly discussed one in this type two category