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Although injectable fillers are often considered the most accessible solution for volume restoration, treating large-volume deficits with fillers alone may lead to an unnatural appearance and the so-called overfilled syndrome, characterized by impaired facial expression [91]

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To intuitively summarize the core mechanisms of heat stress-induced hepatocyte death and their therapeutic relevance, Fig

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Consistency is key to fading pigmentation and maintaining brightness

The practical upshot is that the two headline effects should be tracked as distinct outcomes, not bundled