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The largest, by far, is the ocean, accounting for 97% of the total water volume at Earths surface

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Significantly, genetically engineered uricase knockout mice demonstrate marked increase in serum urate (from a normal level of ~1-2 mg/dL to ~10 mg/dL), highlighting the importance of the loss of uricase in human evolution

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Consequently, cGAS evades p62-mediated autophagic degradation and can stimulate type I IFN signaling after viral infection (156)

The Bottom Line Chronic inflammation is the quiet force behind disease and premature aging