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Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023
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"We'll need to do more research to see if semaglutide can, rarely, cause severe hypoglycemia or if people are starving themselves
This effect persists even in patients who achieve modest weight loss, suggesting a metabolic benefit independent of body mass changes alone
Commercial Codes: Use 45378 (Diagnostic Colonoscopy) with Modifier 33
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