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The primary outcome of this study was percentage change in body weight from baseline to 68 weeks, while the key secondary outcome was the proportion of patients achieving a body weight reduction 5%

Mechanisms linking obesity to insulin resistance and type 2 diabetes

The study was conducted between October 2024 and August 2025 and reported following the Reporting of Studies Conducted Using Observational Routinely Collected Health Data for Pharmacoepidemiology (RECORD-PE) statement and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidance 45

Ongoing nutrition and resistance training

Set Realistic Goals and Celebrate Milestones to Stay Motivated A clear plan helps people stay focused when progress feels slow or when side effects make them question if the journey is worth it