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We have also shown that GH-induced insulin resistance is associated with suppressed pyruvate dehydrogenase activity in skeletal muscle (101)

It is certain that while B1 cells from the spleen did not die of iron during GPX4 deficiency, B1 cells taken from the abdominal cavity of mice experienced a higher degree of ferroptosis at the time of GPX4 defect (166) ( Figure 3 )

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