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Some patients find that symptoms which were tolerable initially become more burdensome over time, and this is a valid reason to reconsider treatment

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However, up to 40% of this weight loss can come from lean muscle tissue , not just fat

[1] [2] As with any medication, understanding the full safety profile, including potential effects on renal health, is essential for appropriate patient counseling and monitoring

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However, optimal doses appear tissue- and application-specific, with lower doses often sufficient for gastrointestinal applications while musculoskeletal injuries may benefit from higher dosing