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I think it will be interesting once we start to see whether the combination of GLP-1s with other compounds that impact the glutamate pathway, particularly in the brain, will have meaningful impact on neurodegenerative diseases

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54 GLP-1 receptor activation delays gastric emptying by inhibiting gastric peristalsis and increasing pyloric sphincter tone, 65 and this effect is more pronounced in individuals exhibiting rapid baseline gastric emptying

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Its goal is systemic saturation, so local injection is unnecessary and wasteful