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Applications include investigating type 2 diabetes prevention, insulin resistance mechanisms, and novel therapeutic approaches for metabolic dysfunction through enzymatic pathway modulation

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Effects of GSTM2 on LD content do not absolutely depend on regulating ROS level Because GSTM2 has antioxidant activity (as described in the Introduction), the potential effect of ROS on cellular lipid formation should be examined

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In humans, metabolically healthy obesity is associated with smaller adipocytes and a lower visceral-to-subcutaneous fat ratio, whereas expansion of visceral fat correlates with systemic insulin resistance and ectopic lipid deposition 46,47,48

Briefly, cells at a density of 2 10 4 per well were plated in a 96 well E-plate containing gold microelectrode sensors on the bottom to measure cellular impedance inside each well