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That triple action is why retatrutide produces stronger weight-loss results than single-receptor drugs like semaglutide

It binds poorly to IGF-binding proteins, which normally sequester IGF-1 in the body, allowing it to remain active and available for a significantly longer period

It also contains regenerative properties linked to the growth hormone

These changes are often more pronounced than Botox or filler because they are structural (actual collagen remodeling) rather than paralysis or filling