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Human trials remain scarce

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Response: We appreciate commenters expressing their concerns on the planned start of ASM on January 1, 2027 and the possibility of negative payment adjustments in the first ASM payment year in CY 2029

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Patients with the following characteristics often see the strongest improvements: Rheumatoid arthritis Psoriatic arthritis Osteoarthritis of the knees or hips Obesity or insulin resistance Chronic fatigue Long-term steroid use Difficulty losing weight despite trying Who Should Avoid GLP-1