Their lean soft tissue changes were -6.9%, +2.5%, and +5.8% respectively, despite total weight loss of 1333%
In a 6-month randomized, placebo-controlled trial in 225 overweight and obese adults aged 18-65, post-hoc factorial analysis showed body fat mass differed by -4.0% versus placebo (P=0.002), waist circumference dropped by 2.4 cm more than placebo, and daily energy intake was reduced by approximately 300 kcal compared to placebo.[8] The trial was not in semaglutide users
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doi: 10.1089/dia.2019.0185
These medications are approved by the FDA, so they match the safety standards