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One recent analysis of six years of medical records from the Department of Veterans Affairs, which reviewed the records of 2 million patients with diabetes, found that those taking a GLP-1 agonist medication had a reduced risk of developing dementia, including Alzheimers, as well as psychiatric and substance use disorders, though it also found an increased risk of gastrointestinal disorders, kidney stones, and pancreatitis

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Such results raise the possibility that semaglutide may influence systems tied not only to metabolism, but also to mood regulation and behavioral control