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These proactive systems minimize misfolding and maintain proteome efficiency during normal physiology, but they are energetically demanding and become insufficient when cells encounter substantial proteotoxic stress

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doi: 10.1378/chest.12-3073 65 TrompetteAGollwitzerESYadavaKSichelstielAKSprengerNNgom-BruCet al

Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice