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The Kronos Early Estrogen Prevention Study (KEEPS, N=727) enrolled women within 36 months of their final menstrual period and found no increase in carotid intima-media thickness or coronary artery calcium scores versus placebo at 4 years [32]

Phase 2 hit -24.2% and Phase 3 TRIUMPH-1 reached -28.3% at 12 mg (investigational)

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