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The presence of comorbid conditions such as obesity and type 2 diabetes also plays a role in interpreting these findings

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Others target specific conditions like gut inflammation or joint recovery that retatrutide does not directly address

Second, CYP2C8 gene polymorphisms were not investigated

Early-week weight loss reflects four primary mechanisms: reduced caloric intake from appetite suppression, decreased water retention as insulin levels normalize, gastric emptying changes slowing digestion, and minor glycogen depletion