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When collagen in the dermis is degraded by UV exposure, aging, or enzymatic activity (matrix metalloproteinases), KTTKS fragments are released as matrikines, endogenous signaling molecules that communicate tissue damage to dermal fibroblasts and trigger a repair response

We subsequently evaluated antifibrotic responses in young (8-week-old) and aged (16-month-old) mouse models, which were established with one-time tracheal instillation of bleomycin

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Transgenic Arabidopsis plants were selected using Basta (10 g/mL)

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