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Mutated PINK1 is characterized by severe oxidative stress-induced cell death (Chien et al
The discrepancy between the 500 mg dose and higher weight-based doses often comes down to absorption
This could prevent cell death, meaning that glutathione could conceivably operate as a neuroprotective agent one that could slow or stop the progression of PD
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Third, although the production rate of ROS is very high, the brain's antioxidant defense system is relatively low due to the high rate of oxidative metabolism and the high content of polyunsaturated fatty acids (PUFA) in the cell membrane 10
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