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In contrast, CCAS is primarily and directly defined as a neuropsychiatric manifestation of cerebellar damages that include significant cerebellar neuropathologies, although many individual components of CCAS are present among signs of other psychiatric syndromes [6, 9, 12]

FIGURE 2 5.2 Clinical application of intranasally delivered drugs Although IN delivery of iron chelators remains in the early preclinical stages and has not yet entered clinical trials, the broader field of IN route has gained increasing attention over the past decade, as evidenced by a notable rise in related clinical studies

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