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Other effects In addition to above effects, GLP-1R agonists have other neuroprotection mechanism on CNS, such as increasing the brain-derived neurotrophic factor (BDNF) levels and activity, regulating calcium homeostasis, promoting glycolysis, and reducing vascular damage

Zanardi R, Smeraldi E

The choice between metformin and GLP-1s, or any other blood sugar lowering medication, should be made based on individual factors, including the patient's medical history, lifestyle, treatment goals, and potential side effects

doi: 10.3389/fmed.2021.689042

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

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