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A disrupted NAD + /NADH balance may contribute to the development of many diseases, including cardiovascular and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, metabolic disorders such as type 2 diabetes, and inflammatory skin conditions such as acne and psoriasis (135137)

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Its often a sign that your cells need deeper support than oral supplements can provide

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Ammonia: a diffusible factor released by proliferating cells that induces autophagy