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The program included eight global trials, four of which included Japanese patients, and two trials conducted in Japan alone

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The OB GLP-1R-induced decrease in sympathetic nerve activity is GABA-dependent and relays via the PVN We next aimed to identify the mechanisms leading to the decrease in SNS activity after activation of the GLP-1R in the OB, which was confirmed by the observed increase in cFos expression in the MCL after local Ex4 injection (Fig

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