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Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide

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GLP analogs (other than lixisenatide) are contraindicated in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) or a family history of medullary thyroid carcinoma

Davis RA, Hui TY

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You might have heard about phentermine, a well-known appetite suppressant