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Whilst Saxenda does act on brain regions involved in appetite control, it does so through physiological GLP-1 receptor activation rather than non-specific neurotransmitter manipulation

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Future research must prioritize rigorous translational frameworks that integrate molecular, neurophysiological, and behavioral data across species

Zepbound is more effective for weight loss, so switching is typically not going to be more beneficial, says Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

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