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In addition, in cultured human tubular cells, cisplatin reduced SIRT3, resulting in mitochondrial fragmentation, while restoration of SIRT3 with ALC (200 or 500 mg/kg b.w., i.p .) improved cisplatin-induced mitochondrial dysfunction [102]

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Researchers who fail to account for dilution ratios consistently report 'no effect' outcomes that are artifacts of insufficient dosing rather than peptide inefficacy