It is the most advanced peptide in this category, activating three metabolic pathways at the same time, which results in a stronger effect on appetite suppression and fat burning compared with semaglutide (1 pathway) or tirzepatide (2 pathways)
How It Works / Key Ingredients This formula augments the actions of MultiThera multivitamin formulas with nutrients known to enhance intracellular levels of glutathione, glutathione peroxidase, and superoxide dismutase (SOD)crucial antioxidants that protect hepatocytes and help detoxify everyday foreign substances
PMCID: PMC5660121 Sande PH, Dorfman D, Fernandez DC, Chianelli M, Domnguez Rubio AP, Franchi AM, Silberman DM, Rosenstein RE, Senz DA
Biol Chem 384:50516 Lu GD, Shen HM, Chung MC, Ong CN (2007) Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells
The SELECT trial (Lincoff and colleagues) of semaglutide in overweight or obese adults with established cardiovascular disease but without diabetes found a 20% reduction in major heart events
[See Warnings and Precautions (5.4).] Risk Summary The limited available data with JANUVIA in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage
