A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression
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We further examined whether acute tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist recently approved by the FDA for obesity, and retatrutide, an investigational triple agonist targeting GIP, GLP-1, and glucagon receptors currently in Phase 3 trials would recapitulate or enhance these effects
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The most frequently reported symptoms included: Nausea (the most common, with rates varying by dose readers should refer to the published trial data and supplementary tables for dose-specific figures) Vomiting Diarrhoea Constipation Upper abdominal pain or discomfort Decreased appetite These effects are largely attributable to the drug's action on GLP-1 receptors in the gastrointestinal tract, which slow gastric motility and alter gut hormone signalling
