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BMI of 27 or higher if you have weight-related health issues (like high blood pressure, Type 2 diabetes, or high cholesterol)

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The SURMOUNT-4 trial presents another opportunity for tirzepatide to differentiate from Novos semaglutide

A strong inhibitory effect on MLF has been observed when lactic acid levels are 4 g/L or higher (Morata et al., 2020a), and it is even delayed at concentrations above 2 g/L

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Broadly speaking, this work signals a shift towards integrating tobacco treatment within chronic disease management frameworks, encouraging clinicians and policymakers to view smoking cessation not as a standalone behavioural goal, but as part of comprehensive cardiometabolic risk reduction strategies embedded within routine care. Tobacco Use: Public Health Threat Tobacco use remains the leading preventable cause of morbidity and mortality worldwide