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The S-conjugates inside the bile duct can be absorbed by the gut to blood circulation and proceed for renal secretion either being metabolized inside the gut lumen [184] or excreted to feces (as found for the sulfuric acid ester of the carcinogen 1-methylpyrene [185])

Role of other factors on TRP channels and pain In addition to the oxidative stress, several other factors play a role in the induction of CIPN with/without TRP channel activation, including glutamate receptors, neuropeptides, PKC and inflammation

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