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In the gastrointestinal system , these medications slow gastric emptying and reduce appetite through central nervous system pathways, contributing to weight loss

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doi: 10.1186/s12933-015-0177-4 68 ZhangYZhouHWuWShiCHuSYinTet al

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Thus, the search for non-peptide oral GLP-1 RAs to overcome absorption difficulty, and the progress of orforglipron without these administration restrictions, are very welcome

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