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When combined with anti-PD-1 therapy, this approach completely eradicated microsatellite instability-high (MSI-high) tumors and significantly reduced the size of microsatellite stable (MSS) tumors (74)

GPX4-independent pathways, including FSP1/CoQ10, DHODH, and GCH1/BH4, all contribute significantly [56,60-62] (Figure 1)

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