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found that exendin-4 could reduce the resistance of prostate cancer cells to enzalutamide by targeting the PI3K/AKT/mTOR pathway, while combined use of exendin-4 and enzalutamide could significantly inhibit the growth of prostate cancer cells (210)
In 2014, they reported a tri-agonist targeting GLP-1R/GIPR/GCGR , demonstrating superior efficacy in mouse experiments [11]
In these cases, a subcutaneous injection is administered as close to the site of interest as possible
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