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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, et al: Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity

Zinc rounds out the formula as your protective shield

Nat Rev Drug Discov 20:689709 Gerber PA, Rutter GA (2017) The Role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus

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Further research is needed to clarify the mechanisms underlying prediabetes reversal following treatment with incretin-based AOM