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Preliminary safety and pharmacokinetics data for A phase 1b trial of telaglenastat in combination with radiation therapy and temozolomide in patients with idh-mutant grade 2/3 astrocytoma (Nci-10218)
However, the blue oral pigmentation seen with long-term minocycline therapy actually represents insoluble salts of the metabolic degradation of the drug
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TFEB (facteur de transcription EB), dans des conditions de stress lysosomal induit par des lipides athrognes tels que les LDL oxydes, dclenche la biogense lysosomale, notamment une expression accrue du gne LIPA (Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae 2014)
The Journal of endocrinology