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However, it has previously been demonstrated that TMAO supplementation markedly downregulated the expression of critical enzymes in bile acid biosynthesis (CYP7A1 and CYP27A1) and hence reduced the size of the bile acid pool (Koeth et al., 2013)

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This review synthesizes evidence from peer-reviewed studies published between 2020 and 2026, prioritizing systematic reviews, meta-analyses, and large-scale clinical trials from PubMed-indexed journals

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Its important to note that individual responses to medications can vary, and what works for one person may not work for another

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