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The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)
But people who avoid animal products can get an adequate supply through fortified breakfast cereals and nutritional yeast
doi:10.14814/phy2.12893 Trommelen et al
Signs & Symptoms Symptoms vary substantially by fiber type and distribution
however, competition from dissolved organic matter for active sites reduces adsorption efficiency and operational longevity
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