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It suppresses IL-6 and TNF- production while enhancing IL-10 production in macrophages, and inhibits the mTOR/STAT3 pathway in T cells, thereby reducing proinflammatory Th17 cells and cytokines such as IL-17 and IL-22, while promoting regulatory T-cell (Treg) differentiation (21)

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Habeners remarkable scientific achievements were recognized internationally, including his receipt of the 2019 Harold Hamm award, the 2021 Gairdner award, the 2024 Lasker-DeBakey Clinical Medical Research Award, shared with colleagues for their collective contributions to GLP1based therapeutics

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