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Individuals with pre-existing health issues such as liver disease, kidney problems, or those undergoing chemotherapy should be especially cautious

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1,2 Drugs like liraglutide and exenatide have been used as add-ons to insulin treatment in individuals with type 1 diabetes .1,2 While liraglutide and exenatide were successful in reducing body weight, liraglutide was reported to increase hypoglycaemia

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Upon ligand binding, GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, collectively improving glycemic control and promoting clinically meaningful weight reduction [19]

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