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GLP-1 RAs were initially approved for the treatment of type 2 diabetes mellitus (T2DM)

Hyperuricemia continues to be inadequately managed, primarily due to factors such as ineffective dosing of urate-lowering therapy, patient noncompliance, and intolerance/adverse events associated with current treatment options

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The mechanism by which these medications might theoretically affect sleep is not well understood, and current evidence does not support a direct pharmacological effect on sleep architecture or dream patterns

Tell your prescribing clinician so the baseline B12 level interpretation accounts for supplementation (a patient taking 1,000 mcg/day will have a falsely reassuring serum level even if tissue stores are low, because serum B12 reflects recent intake, not body reserves)