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Treatment with NR or the PARP inhibitor Olaparib also improved mitochondrial morphology in aged nematodes and mammalian muscle cells during proteotoxic stress 114

A groundbreaking study revealed that bacterial DNA containing unmethylated CpG motifs activates innate immunity via the TLR9MyD88 pathway, while mammalian DNA exhibits immune tolerance due to methylationmediated blockade of TLR9 binding [117,118,119]

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[PMID: 33795830 DOI: 10.1038/s41379-021-00793-y] [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Huang SH

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